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Journal: ACS Bio & Med Chem Au
Article Title: High Drug Encapsulation Capacity in Cyclodextrin-Based Nanoparticles: Characterization and In Vivo Antitumor Efficacy in Tumor-Bearing Mice
doi: 10.1021/acsbiomedchemau.5c00220
Figure Lengend Snippet: (A) Cryo-TEM images of MGS encapsulated in CDNP_PEG_4. The scale bar is 200 nm. (B) The scale bar is 50 nm. SAXS measurement of CDNP with Encapsulated MGS. (C) Comparison of SAXS profiles with and without MGS encapsulation in CDNP_PEGs and CDNP_ECH with MGS encapsulation. (D) SAXS results with different feeding concentration of MGS. Change in drug encapsulation ratio in (E) and [MGS]/[CD] in (F) as a function of MGS concentration. (G) Relationship between CD density ratio and [MGS]/[CD] in particles. (H) The mechanism of structural changes anticipated with drug encapsulation. Data are presented from a single experiment ( n = 1).
Article Snippet:
Techniques: Comparison, Encapsulation, Concentration Assay